This presets the classic story of how five astronauts go to space to study DNA. They are hit with a solar flash, four of them while outside the vehicle, and their DNA is altered, Reed Richards/Mr. Fantastic, Sue Storm/Invisible Woman, brother Johnny Storm/Human Torch and Ben Grimm/The Thing (Ioan Gruffudd, Jessica Alba, Chris Evans and Michael Chiklis). The movie deals with their coming to terms with their changes. The Thing struggles the most, as his fiancé breaks off the relationship due to his changed appearance (he looks like a rock.). Richards, the lead scientist vows to find a way to reverse the machine, creating a controlled solar storm. Mean while te fifth member of the company, Victor von Doom/Dr. Doom (Julian McMahon) begins to develop his own powers, unbeknownst to the others. His body is turning to metal and can generate electricity. While the Fantastic Four use their powers for good, Doom uses his powers to murder others, and wants to take the powers of the oter four so he will be the only one with powers. He cures the thing for a time, using his generated electricity to have the power needed. This leads to a battle between Dr. Doom and the Four.
The Thing finally meets a woman who accepts him as he is, Alicia Masters (Kerry Washington). He seems to be more accepting of himself as a result.

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